Blood Vessel Function and Target-Organ Damage / Registry Diabetic Nephropathy

Blood Vessel Function and Target-Organ Damage / Registry Diabetic Nephropathy
Gollasch, Maik

Our group focuses on ion channels, primarily in vascular smooth muscle cells (VSMC), to clarify mechanisms contributing to hypertension, renal and cardiovascular disease. Potassium channels, chloride channels and transient receptor potential (TRP) channels have received special attention. We are currently studying biased agonism and ryanodine receptor isoforms in VSMC potassium channels’ gating and myogenic tone. We also have a project focusing on the perivascular adipose tissue (PVAT) as a source for relaxing factors. We continue to work on the novel concept that perivascular adipose tissue (PVAT) function requires considering heterogeneous PVAT as a specialized organ that can differentially regulate vascular function depending on its anatomical location. Adipocyte-derived relaxing factor (ADRF) and its putative targets (KCNQ channels) might represent exciting new targets. In collaboration with Bernd Nürnberg (Tübingen), current research is also directed towards the discovery of novel mechanisms underlying TRPC6 and TRPV4 related kidney pathologies. We have performed functional analyses of mutations causing familiar kidney diseases with specific emphasis on TRPC6 channels in focal and segmental glomerulosclerosis (FSGS). We identified a unique CD2AP mutation in a German family, supporting the overall concept that CD2AP-associated nephropathy is an autosomal dominant form of FSGS in man. We are also studying human diabetic nephropathy with a focus on genetics. For this purpose, we established an Outpatient Kidney Clinic at the MDC Campus Berlin Buch (https://www.mdc-berlin.de/8233420/en/research/themes/translation/ecrc, http://www.hochschulambulanz-charite-buch.de/) and the Registry of Diabetic Nephropathy (http://www.charite-buch.de/rdn/). We are continuously recruiting patients for our Registry and renal/vascular disease-specific family studies. Through these studies, we hope to identify novel mechanisms leading to increased cardiovascular risk and target-organ damage and novel treatment targets.

 

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Blood Vessel Function and Target-Organ Damage / Registry Diabetic Nephropathy