Physiology and Pathophysiology of Renal Acid-Base and Oxalate Excretion

Physiology and Pathophysiology of Renal Acid-Base and Oxalate Excretion
Physiology and Pathophysiology of Renal Acid-Base and Oxalate Excretion
Aronson, Peter
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Our general goal is to characterize the mechanisms regulating sodium, acid-base, and anion excretion by the kidney. Our work is primarily focused on membrane transport proteins mediating ion exchange, namely NHE isoforms mediating Na-H exchange, and SLC26 isoforms mediating anion exchange. One approach involves the generation of isoform- and phospho-specific polyclonal and monoclonal antibodies to identify the cellular and subcellular sites of expression of ion exchangers in the kidney and other tissues, and to study their regulation. A complementary approach uses mice with targeted gene disruption to elucidate the physiological roles of ion exchangers and associated proteins under in vivo conditions. For example, work with mice lacking anion exchanger Slc26a6, which can function as an oxalate transporter, revealed a phenotype of calcium oxalate kidney stones. This finding in turn has motivated studies on the mechanisms and regulation of oxalate transporters and their roles in oxalate homeostasis, urolithiasis, and crystal-induced inflammation and kidney disease.

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Physiology and Pathophysiology of Renal Acid-Base and Oxalate Excretion