Acute kidney inflammation

Acute kidney inflammation
Acute kidney inflammation
Salama, Alan

We are interested in inflammatory renal disease, which can affect different parts of the kidney, specifically the glomeruli or the tubules and lead to rapidly declining kidney function.
1.Glomerulonephritis
Each year around a thousand people in the UK develop vasculitis, an inflammation of small blood vessels. When it affects the kidneys, this form of glomerulonephritis is one of the commonest causes of kidney failure requiring dialysis or transplantation. It is often sudden in onset and sometimes associated with bleeding from the lung, frequently affecting those who were otherwise well. Our research aims to find ways to control this inflammation without disabling the body’s immune system that normally protects against infection and cancer. Vasculitis is rare and the diagnosis can be missed, and even following diagnosis it may also relapse, so we are trying to find better disease markers for earlier detection, to monitor its progress, and to predict earlier relapses. Finally, we are investigating rare cases of patients who have switched off their disease to understand if we can define a marker that helps us predict when we can stop immunosuppressive therapy. To better understand the outcomes of patients outside of clinical trials, we have established a UK registry of all affected vasculitis patients, which is expanding and will allow us to define demographics more clearly.
2. Ischaemia and acute tubular injury
Following ischaemia, certain drug therapies, or contrast agents there is an inflammatory response in the kidney which leads to acute tubular injury. We have found that the level of a protein, the mannose receptor, influences kidney damage in this context and are developing novel ways to block this particular molecule, with a view to developing a strategy for preventative treatment of patients at high risk of acute tubular injury.

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Acute kidney inflammation