Polycystic kidney disease

Polycystic kidney disease
Polycystic kidney disease
Wilson, Patricia
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Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common genetic cause of CKD affecting approximately 60,000 patients in the United Kingdom and ~12 million worldwide. Kidney cysts develop and close off from developing renal tubules and continue to expand and enlarge due to excessive epithelial cell proliferation and apical fluid secretion over many years. Our translational research is focused on: 1) The identification and evaluation of potential therapeutic drug targets, including EGFR/ErbB1/ErbB2 and PDGF, to slow down cystic expansion and fibrotic accumulation associated with progressive renal functional decline in ADPKD and 2) The identification and characterization of specific urinary and blood exosomal and biomarker profiles to improve prognosis by predicting rates of disease progression and to monitor responses to tailored therapies.

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Polycystic kidney disease