Progression and Complications of CKD

Progression and Complications of CKD
Progression and Complications of CKD
Caplin, Ben

Our research interests surround the progression and complications of chronic kidney disease (CKD) with a focus both on population studies and translation into the laboratory. We work closely with Dr Jill Norman and Professor David Wheeler within the Centre for Nephrology as well as collaborators across UCL and at the London School of Hygiene and Tropical Medicine.

We have a longstanding aim to better understand the cardiovascular consequences of impaired kidney function. Specifically our focus is on the stiffening and thickening of the muscle layer that occurs in the arteries of patients with CKD. Currently we are investigating this process using histological and molecular biological approaches in blood vessels donated by patients undergoing renal transplantation.

More recently we have developed a research interest in regional endemic nephropathies, also called CKD of non-traditional causes (CKDnt). CKDnt is an increasingly important, though probably still vastly under-recognised, cause of death amongst agricultural communities in tropical underdeveloped regions around the world. The cause(s) of CKDnt are still poorly understood. To this end, Ben Caplin is co-principal investigator of a community-based cohort study investigating the aetiology and natural history of CKDnt in Pacific Coast Central America. We are currently using biosamples from this study to examine a number of the leading hypotheses as to the cause of CKDnt.

Alongside his research work Ben Caplin also co-manages the academic team delivering the NHS National CKD Audit, which aims to quantify the burden and management of CKD across the entire primary care registered population of England and Wales.

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Progression and Complications of CKD